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Is lymphoma considered an autoimmune disease?
Non-Hodgkin lymphoma (NHL) is a malignancy of the immune system, plausibly associated with autoimmune and inflammatory diseases [9].
Do B cells cause autoimmune disease?
B cells serve as APCs in autoimmune diseases including rheumatoid arthritis and type 1 diabetes [61, 62].
What autoimmune causes lymphoma?
Some autoimmune diseases such as rheumatoid arthritis, systemic lupus erythematosus (SLE or lupus), Sjogren (Sjögren) disease, celiac disease (gluten-sensitive enteropathy), and others have been linked with an increased risk of NHL.
Does lymphoma cause positive ANA?
Conclusion: In conclusion, ANA and related autoantibodies can frequently be detected during lymphoma treatment. However, the majority of lymphoma patients with positive ANA did not display autoimmune diseases, demonstrating the lack of a strict correlation between the presence of ANA and autoimmune diseases.
Which type of lymphoma is curable?
Hodgkin lymphoma is considered one of the most treatable cancers, with more than 90 percent of patients surviving more than five years. Most patients with Hodgkin lymphoma live long and healthy lives following successful treatment.
Can stress cause lymphoma?
There is no evidence that stress can make lymphoma (or any type of cancer) worse. Remember: scientists have found no evidence to suggest that there’s anything you have, or have not done, to cause you to develop lymphoma.
What triggers lymphoma?
Doctors aren’t sure what causes lymphoma. But it begins when a disease-fighting white blood cell called a lymphocyte develops a genetic mutation. The mutation tells the cell to multiply rapidly, causing many diseased lymphocytes that continue multiplying.
What diseases can mimic lymphoma?
Benign etiologies of lymphadenopathy can include infections, autoimmune disorders, drug hypersensitivity reactions, sarcoidosis, and amyloidosis. Rare but benign lymphoproliferative disorders include Kikuchi’s disease, Rosai-Dorfman disease, and progressive transformation of germinal centers.
What are B-cell diseases?
A primary feature of autoimmune diseases is the loss of B-cell tolerance and the inappropriate production of autoantibodies. More than 80 distinct autoimmune diseases have been described, such as multiple sclerosis (MS), rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE).
How do you keep B cells healthy?
These strategies might include:
- eating a diet rich in fruits and vegetables.
- exercising regularly.
- maintaining a healthy weight.
- quitting smoking.
- drinking alcohol only in moderation.
- getting enough sleep.
- avoiding infection through regular hand washing.
- reducing stress.
Which drugs are B-cell depleting?
Table 1
| Agent | Type of Therapy | B-cell Lineages Affected |
|---|---|---|
| Rituximab | Anti-CD20 | From pre-B cells to memory cells |
| Ocrelizumab | Anti-CD20 | From pre-B cells to memory cells |
| Ofatumumab | Anti-CD20 | From pre-B cells to memory cells |
| Epratuzumab | Anti-CD22 | Mature CD27 cells |