What is the benefit of combination therapy?
Combination therapy has been shown to dramatically reduce the likelihood of drug resistance (many drug-resistant mutations are mutually exclusive) and to suppress viral replication to the point that progression to AIDS is significantly slowed.
When is combination therapy used?
Uses. Conditions treated with combination therapy include tuberculosis, leprosy, cancer, malaria, and HIV/AIDS. One major benefit of combination therapies is that they reduce development of drug resistance since a pathogen or tumor is less likely to have resistance to multiple drugs simultaneously.
What are treatment combinations?
Combination treatments, sometimes called multimodal treatments, refer to the use of two or more kinds of therapies. Different kinds of therapies may be used in sequence, at the same time, or in various timing formats.
Why chemotherapy is used in combination with radiation therapy?
In the treatment called chemo-radiation, you will get both chemotherapy and radiation at the same time. Chemotherapy weakens the cancer cells which helps radiation to work better. Your treatment team consists of your medical oncologist and your radiation oncologist.
Why Antibiotics are given in combination?
Combination therapy is mostly practiced because of one or more of the following reasons: Broadening antibacterial spectrum. Use of more than one agent broadens the antibacterial spectrum of the empirical therapy and thus ensures that at least one agent will cover the infecting organism.
Why is combination therapy better than monotherapy?
This superior effectiveness of combined therapy relates to a better antihypertensive efficacy and higher response rates in the low range of doses as the result of complementary mechanisms of antihypertensive effects, better tolerance as a result of a lower rate of adverse effects in the low dose range, improved …
What treatments or combination of treatments are most effective?
Research generally shows that psychotherapy is more effective than medications, and that adding medications does not significantly improve outcomes from psychotherapy alone.
What is the best combination of antidepressants?
Sertraline and escitalopram come out on top
Using fluoxetine as the reference medication, the researchers analyzed various second-generation antidepressants. Sertraline and escitalopram had the best combination of efficacy and acceptability.
Why are drugs given in combination?
The use of drugs in combination can produce a synergistic effect if each of the drugs impinges on a different target or signaling pathway that results in reduction of required drug concentrations for each individual drug. Therefore, use of drug combinations could increase the success rate of drug repurposing screens.
What is an example of randomization?
The most common and basic method of simple randomization is flipping a coin. For example, with two treatment groups (control versus treatment), the side of the coin (i.e., heads – control, tails – treatment) determines the assignment of each subject.