Best answer: Why is cytarabine effective in treating cancer?


How does cytarabine treat cancer?

Cytarabine is also used alone or with other chemotherapy drugs to treat meningeal leukemia (cancer in the membrane that covers and protects the spinal cord and brain). Cytarabine is in a class of medications called antimetabolites. It works by slowing or stopping the growth of cancer cells in your body.

What is the mechanism of action of cytarabine?

Mechanism of Action

Cytarabine is a pyrimidine analog and is also known as arabinosylcytosine (ARA-C). It is converted into the triphosphate form within the cell and competes with cytidine to incorporate itself in the DNA. The sugar moiety of cytarabine hinders the rotation of the molecule within the DNA.

What is cytarabine used for?

What Cytarabine Is Used For: Cytarabine is used to treat different forms of leukemia, including acute and chronic myelogenous leukemia (AML and CML), acute lymphocytic leukemia (ALL), and acute promyelocytic leukemia (APL).

Is cytarabine a strong chemo?

Cytarabine is a type of chemotherapy drug and is also known by its brand name, Ara C. It is a treatment for: acute leukaemias (cancers of the blood) some lymphomas (cancers of the lymph glands)

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Does cytarabine cause hair loss?

This medicine may cause a temporary loss of hair in some people. After treatment with cytarabine has ended, normal hair growth should return.

How effective is cytarabine?

The overall survival data with the use of cytarabine in conventional and high dose regimen is approximately 40% with remission rates of 70–80% and relapse-free 5 years survival of 40-70%[15]. Standard intensive treatment improves early death rates and long-term survival compared with palliation.

Which phase of the cell is most affected by cytarabine?

Cytotoxicity is highly specific for the S phase of the cell cycle. Cytarabine acts through direct DNA damage and incorporation into DNA.

Which phase is affected by cytarabine?

Its mode of action is due to its rapid conversion into cytosine arabinoside triphosphate, which damages DNA when the cell cycle holds in the S phase (synthesis of DNA). Rapidly dividing cells, which require DNA replication for mitosis, are therefore most affected.

How does cytarabine prevent replication?

Cytarabine is metabolized to an active drug that inhibits DNA synthesis. Cytarabine is an anti-metabolite synthetic nucleoside analogue. Cytarabine A inhibits DNA polymerase in mitotically active cells and produces topoisomerase dysfunction and prevents DNA repair.

What is the strongest chemo drug?

Doxorubicin (Adriamycin) is one of the most powerful chemotherapy drugs ever invented. It can kill cancer cells at every point in their life cycle, and it’s used to treat a wide variety of cancers.

Can Cytarabine cause neuropathy?

Intravenous (IV) therapy may cause a peripheral neuropathy that varies greatly in its severity. The high IV cytarabine doses now commonly used can cause seizures, cerebral dysfunction, or an acute cerebellar syndrome with an incidence up to 14%.

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How often is Cytarabine given?

Intermittent dosing: Cytarabine may be given as intermittent intravenous doses of 3-5 mg/kg daily, for five consecutive days. This course of treatment can be repeated after an interval of 2 to 9 days and repeated until the therapeutic response or toxicity is exhibited.