Can the mitotic index help to diagnose cancer?

What is the mitotic index used for?

The mitotic index (percentage of cells in mitosis at any time) provides a measure of the capacity of cells to divide and of the rate of cell division. It is used to identify the sites of growth within a tissue and to determine which cell types are dividing.

Do cancer cells have a high or low mitotic index?

Malignancy is characterized by accelerated cell division (high “mitotic index”), which is detectable on proton (1H) MRS (hereinafter “MRS”) as elevated Cho. Cho elevation occurs when there is rapid cell membrane synthesis.

What is mitotic index in cancer?

Listen to pronunciation. (my-TAH-tik IN-dex) In a population of cells, the ratio of the number of cells undergoing mitosis (cell division) to the number of cells not undergoing mitosis.

What is a high mitotic count?

The higher the mitotic count, the more likely the tumor is to have metastasized (spread). The logic is that the more cells are dividing, the more likely they will invade the blood or lymphatic vessels and thus spread around the body.

What does a high mitotic index indicate?

An elevated mitotic index indicates more cells are dividing and is an important prognostic factor predicting both overall survival and response to chemotherapy in most cancer types.

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Do benign tumors have a high mitotic index?

Occasionally, the mitotic rate in benign tumors may be brisk, and those with mitotic activity up to 15 mitoses/10 hpf are termed leiomyomata with increased mitotic activity (Fig. 20.81; see Table 20.7).

What is the average mitotic index?

Labelling and mitotic indices were studied in the epidermis of twenty-eight young men. A mean labelling index of 5.5% was found from the whole study and a mean mitotic index of 0.06%. Mitotic index particularly was extremely variable; indices between 0.002 and 0.438% were found in individual biopsies.

What is a normal mitotic rate?

The mitotic rate of normal epidermis from adult men and women measured over a 5 hr. period (using colcemid) is 1-44 and 117 mitoses per 1000 viable epidermal cells, respectively. The duration of mitosis of normal epidermis is approximately 90 min.

What is a mitotic count?

Mitotic count is determined most frequently in veterinary pathology, usually at 400× magnification, but the area counted is seldom defined, and the term often reported is mitotic index. Mitotic index is defined as the number of cells undergoing mitosis divided by the number of cells not undergoing mitoses.