Can we cure refractory Hodgkin’s lymphoma with transplantation?

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Can refractory lymphoma be cured?

The prognosis for these patients is poor, especially for those who have high-risk factors such as secondary IPI score >2 or relapse ≤12 months post-ASCT. Thus, most patients with refractory DLBCL have no curative treatment options.

How I treat relapsed and refractory Hodgkin lymphoma?

Relapsed or refractory Hodgkin lymphoma is a challenging problem for clinicians who treat hematologic malignancies. The standard management of these patients should include the use of salvage chemotherapy followed by autologous stem cell transplant (ASCT) in patients who are chemotherapy sensitive.

How is refractory non Hodgkin lymphoma treated?

The current standard of care for the first-line treatment of DLBCL is chemotherapy with rituximab plus cyclophosphamide, hydroxydaunorubicin, vincristine and prednisolone (R-CHOP), yielding complete and sustained remission in about 60% of cases (Coiffier et al, 2002).

Can you live a long life after lymphoma?

Considering everyone with non-Hodgkin lymphoma—all people with all types of this cancer—the overall five-year survival rate is 69%. That means about 7 of 10 people are still living five years after diagnosis. The overall 10-year survival rate is about 60%.

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How long can you live with lymphoma without treatment?

Overall, 50 to 60 percent of patients with non-Hodgkin lymphoma now live five years or longer without a recurrence.

How serious is Hodgkin’s lymphoma?

Hodgkin’s lymphoma is treatable, especially in its early stages. The one-year survival rate for all patients diagnosed with Hodgkin’s lymphoma is about 92 percent. The five-year survival rate is about 86 percent. For people with stage 4 Hodgkin’s lymphoma, the survival rate is lower.

Can Hodgkin’s lymphoma turn into leukemia?

Some survivors of Hodgkin lymphoma have a higher risk of developing a secondary cancer, especially acute myeloid leukemia (after certain types of chemotherapy, like BEACOPP, or radiation therapy), non-Hodgkin lymphoma, lung cancer, or breast cancer.

Is Hodgkin’s lymphoma recurrence?

A small proportion of people with Hodgkin lymphoma or with other types of high-grade non-Hodgkin lymphoma might also relapse. Most relapses of Hodgkin lymphoma or high-grade non-Hodgkin lymphoma happen within the first 2 years after treatment. As time goes on, relapse generally becomes less likely.

How long can you live after Hodgkin’s lymphoma?

The five-year survival rate refers to the percentage of patients, according to the stage of their disease at diagnosis, who live at least five years after treatment for Hodgkin lymphoma. Many of these patients live longer than five years.

How long does it take to recover from Hodgkin’s lymphoma?

There are very few cancers for which doctors will use the word cure right off the bat, but Hodgkin lymphoma (HL), the most common cancer diagnosis among children and young adults, comes pretty darn close: Ninety percent of patients with stages 1 and 2 go on to survive five years or more; even patients with stage 4 have …

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What is refractory non Hodgkin’s lymphoma?

Some patients still have lymphoma cells in their bone marrow after NHL treatment. This is called refractory non-Hodgkin lymphoma. Some patients have a return of lymphoma cells in the marrow and a decrease in normal blood cells after remission.

What is refractory Hodgkin lymphoma?

The term “refractory” is used to describe when the lymphoma does not respond to treatment (meaning that the cancer cells continue to grow) or when the response to treatment does not last very long.

How do you treat refractory diffuse large B cell lymphoma?

Rituximab with cyclophosphamide, doxorubicin, vincristine, and prednisone is the current frontline standard-of-care treatment for DLBCL and has been shown to cure almost 60% of cases in younger and elderly patients.