Does high AFP mean cancer?
Increased AFP levels may indicate the presence of cancer, most commonly liver cancer, cancer of the ovary, or germ cell tumor of the testicles. However, not every liver, ovarian, or testicular cancer will produce significant quantities of AFP.
How accurate is AFP test for cancer?
Levels of AFP >20 ng/mL detected HCC with 70.1% sensitivity and 89.8% specificity.
How common is high AFP?
There are approximately 25 to 50 abnormal test AFP results for every 1,000 pregnancies tested. Of these abnormal results, only 1 in 16 to 1 in 33 will actually have a baby that has been affected by a neural tube defect or other condition.
Can tumor markers be elevated without cancer?
Tumor markers are substances found in the blood. Tumor marker levels may be higher when there is cancer in the body. They are not very “specific,” meaning non-cancer health issues can also cause these levels to be higher. They must be used along with radiology tests and exams by your healthcare provider.
What is an abnormal AFP result?
What do the results mean? If your results show higher than normal AFP levels, it may mean your baby has a neural tube defect such as spina bifida, a condition in which the bones of the spine don’t close around the spinal cord, or anencephaly, a condition in which the brain does not develop properly.
What happens if AFP is high?
What do the results mean? If your results show high levels of AFP, it may confirm a diagnosis of liver cancer, or cancer of the ovaries or testicles. Sometimes, high levels of AFP can be a sign of other cancers, including Hodgkin disease and lymphoma, or noncancerous liver disorders.
What happens if an AFP test is positive?
What does it mean if my AFP PLUS test result is screen positive? A positive AFP PLUS test means that you are in a higher likelihood group for having a baby with a neural tube defect or a chromosome abnormality. However, it does not prove by itself that there is anything wrong with the pregnancy.
How do I lower my AFP?
Iron reduction therapy significantly reduced the median level of serum AFP from 13 to 7 ng/mL, ALT from 96 to 50 IU/L, gamma-glutamyl transpeptidase (GGT) from 55 to 28 IU/L, and ferritin from 191 to 10 ng/mL ( for each).
Can fatty liver cause elevated AFP?
The presence of hepatic inflammation and/or fibrosis may be the underlying cause of increased serum AFP levels in patients with severe fatty liver. Necrosis or active regeneration may also play a role in these patients.
What does AFP test look for?
The results of your AFP blood test can alert your doctor to possible birth defects. A high level of AFP can be an indication of a neural tube defect such as spina bifida. It can also indicate chromosomal problems in the developing baby.
Does AFP testing tell gender?
Non-Invasive Prenatal Screening
It does screen for an increase in chromosomes 21, 18, and 13. It also can detect the gender of baby. It does not screen for all chromosomes.