How basal are triple negative breast cancers?


What is the difference between basal-like and triple-negative breast cancer?

Basal-like breast cancer is similar to triple-negative breast cancer because the cancer cells often don’t have receptors for estrogen, progesterone and HER2. But basal-like breast cancer cells have changes in the proteins that triple-negative breast cancers usually don’t have.

Is TNBC basal-like?

Gene expression profiling analysis often classifies TNBC as a subtype of basal-like breast cancer (BLBC). Approximately 56% of TNBC and BLBC gene expression profiles overlap.

How bad is triple-negative breast cancer?

Usually TNBC presents as a high-grade infiltrating ductal carcinoma and almost all are grade 3 tumors. TNBC is significantly more aggressive than any other breast cancer. It is chemotherapy sensitive, but its victims have a median overall survival of approximately 13 to 18 months with standard chemotherapy.

Are there different types of triple-negative breast cancer?

Triple-negative breast cancer (TNBC) has been subdivided into six distinct subgroups: basal-like 1 (BL1), basal-like 2 (BL2), mesenchymal (M), mesenchymal stem–like (MSL), immunomodulatory (IM), and luminal androgen receptor (LAR).

What is basal-like tumor?

Basal-like breast cancer (BLBC) is a particularly aggressive molecular subtype defined by a robust cluster of genes expressed by epithelial cells in the basal or outer layer of the adult mammary gland. BLBC is a major clinical challenge because these tumors are prevalent in young woman, often relapsing rapidly.

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What are basal markers?

Purpose: Basal marker expression in triple-negative breast cancers identifies basal-like tumours, and thus separates the TN group into two prognostic groups. However, the expression and prognostic significance of basal markers in luminal breast cancers are poorly described.

Is TNBC a death sentence?

Fact: TNBC is not a death sentence! Make sure patients know there are effective treatments for this disease, and people can survive. Be sure to point out that TNBC is particularly sensitive to chemotherapy, and many clinical trials are available if standard treatment is ineffective.

How long is chemo for triple-negative breast cancer?

A standard triple-negative chemo regimen is 12 weeks of taxol, followed by four doses of adriamycin and cytoxan. In the new study, doctors gave patients an additional chemo drug called carboplatin.

Is triple-negative breast cancer the worst kind?

Triple-negative breast cancer is considered to be more aggressive and have a poorer prognosis than other types of breast cancer, mainly because there are fewer targeted medicines that treat triple-negative breast cancer.

Can stress cause triple-negative breast cancer?

Social stress connected to triple-negative breast cancer via fat cells. Local chemical signals released by fat cells in the mammary gland appear to provide a crucial link between exposure to unrelenting social stressors early in life and to the subsequent development of breast cancer, according to new research.