How is excess lifetime cancer risk calculated?

What is excess lifetime cancer risk?


The incremental excess lifetime cancer risk IELCR is the probability of developing cancer as the result of exposure to a specific carcinogen and appears as an incremental increase in cancer cases in the exposed population over what would occur in the absence of exposure.

How is cancer slope factor calculated?

This term specifies the length of time over which the average dose is calculated. For quantifying cancer risk a “lifetime” of 70 years is used (i.e, 70 years times 365 days/year). SF = Cancer slope factor (mg/kg-day) ADAF = Age-dependent adjustment factor for age bin “i” (unitless)

How do you calculate lifetime risk?

The ‘lifetime risk’ of cancer is generally estimated by combining current incidence rates with current all-cause mortality (‘current probability’ method) rather than by describing the experience of a birth cohort.

How do you calculate carcinogenic risk?

For carcinogenicity, the probability of an individual developing cancer over a lifetime is estimated by multiplying the cancer slope factor (mg/kg/day) for the substance by the chronic (70-year average) daily intake (mg/kg-day).

What is chronic daily intake?

Chronic Daily Intake (CDI). Exposure expressed as mass of a substance contacted per unit body weight per unit time, averaged over a long period of time (as a Superfund program guideline, seven years to a lifetime).

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What is oral slope factor?

Oral slope factor–the slope factor used with administered doses to estimate the probability of increased cancer incidence over a lifetime (i.e., excess lifetime cancer risk [ELCR]).

What is Lifetime Gail risk?

The Gail Model is a risk prediction tool that is designed to derive individual risk estimates for the development of breast cancer over time. It was developed to estimate the probability of developing breast cancer over a defined age interval; it was also intended to improve screening guidelines.

What is lifetime risk?

(LIFE-time risk) A measure of the risk that a certain event will happen during a person’s lifetime. In cancer research, it is usually given as the likelihood that a person who is free of a certain type of cancer will develop or die from that type of cancer during his or her lifetime.

What does Gail lifetime risk mean?

The modified Gail 5-year risk score (risk of developing invasive breast cancer during the next 5-year period) and lifetime risk score (risk of developing invasive breast cancer up to age 90) used by the US National Cancer Institute’s Breast Cancer Risk Assessment Tool [103] were calculated for participants who provided …