How often does tamoxifen cause endometrial cancer?

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Does tamoxifen cause endometrial cancer?

Tamoxifen acts as an anti-estrogen in breast tissue, but it acts like an estrogen in the uterus. In women who have gone through menopause, it can cause the uterine lining to grow, which increases the risk of endometrial cancer. The risk of developing endometrial cancer from tamoxifen is low (less than 1% per year).

How long does it take for tamoxifen to cause uterine cancer?

After 2-5 years of receiving tamoxifen, the risk for developing uterine cancer doubled and after 5 years of tamoxifen use the risk for developing uterine cancer increased by a factor of 7.

How much does tamoxifen increase uterine cancer?

Most studies have found that the increased relative risk of developing endometrial cancer for women taking tamoxifen is two to three times higher than that of an age-matched population 1 2 3. The level of risk of endometrial cancer in women treated with tamoxifen is dose and time dependent.

Does tamoxifen cause endometrial thickening?

Endometrial thickness increased with the duration of tamoxifen treatment. Seventy-three women being treated with tamoxifen for less than 5 years had a median endometrial thickness of 5 mm, and 44% of biopsies yielded abnormal results.

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What cancer does tamoxifen cause?

Because tamoxifen acts like estrogen in the uterus, it can increase your risk of endometrial cancer and uterine sarcoma (cancers of the uterus). It also is linked to a higher risk of endometrial pre-cancers.

Can you get cancer while on tamoxifen?

Tamoxifen does, however, increase the risk for uterine cancer (endometrial cancer and uterine sarcoma). Still, the overall risk of uterine cancer in most women taking tamoxifen is low, and studies have shown that the benefits of this drug in treating breast cancer are greater than the risk of a second cancer.

What are the long term side effects of tamoxifen?

Tamoxifen can have side effects, including hot flashes, fatigue, and an increased risk of blood clots and endometrial cancer. But there was no substantial increase in serious side effects, including endometrial cancer incidence or death, in women who took tamoxifen for the longer period, Gray reported.

Can you drink alcohol with tamoxifen?

Alcohol can raise the risk of side effects with tamoxifen, some of which can be serious. Alcohol makes it harder for tamoxifen to work properly and should be limited or avoided while you’re taking this medication. Alcohol can raise your risk of developing breast cancer.

Is it safe to take tamoxifen for 10 years?

A recent study published in the British Journal of Medicine indicated clear evidence that 10 years of tamoxifen therapy does reduce local recurrence and improve breast cancer-free survival. However, it also reported that extended use (10 years rather than five) was linked with a two-fold increase in endometrial cancer.

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Is tamoxifen worth taking?

Wesolowski advises that benefits of taking the drug need to be carefully weighed against risks. “In general, tamoxifen for five years reduces the probability of breast cancer recurrence by almost 50 percent, while risks of serious side effects are at around 1 percent or less,” he explained.

What happens when you stop tamoxifen?

Blood clots in your veins or lungs.

These can occur for up to 2–3 months after you stop taking tamoxifen. Symptoms can include: sudden chest pain. shortness of breath.

Is it normal to have periods while taking tamoxifen?

Fertility, pregnancy and tamoxifen

For some women, continued use of tamoxifen means periods become less regular, lighter or stop altogether. Generally, your periods will start again once you stop taking tamoxifen, as long as you have not gone through the menopause naturally while taking the drug.