Is lobular carcinoma genetic?

Is lobular carcinoma hereditary?

Definition. Hereditary lobular breast cancer is a rare inherited cancer predisposition associated with pathogenic CDH1 (gene) germline mutations, and without apparent correlation with the hereditary diffuse gastric cancer syndrome.

Does lobular carcinoma run in families?

Along with environment and lifestyle, a woman’s genetic background contributes to her risk of having breast cancer. Her risk of developing breast cancer increases if she has a family history of the disease.

Is lobular breast cancer more likely to recur?

Weidner et al. (20) reported that patients with pleomorphic ILC were four times more likely to experience recurrence than patients affected by classic variant and Orvieto et al. (21) conducted an analysis of 530 cases of ILC (57% classic, 19% alveolar, 11% solid, and 13% displayed pleomorphic or apocrine features).

How common is lobular carcinoma?

Lobular breast cancer (also called invasive lobular carcinoma) is a type of breast cancer that begins in the milk-producing glands (lobules) of the breast. It is the second most common type of breast cancer, accounting for about 10% to 15% of all invasive breast cancers.

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Can you survive invasive lobular carcinoma?

Invasive lobular carcinoma survival rates

The average 5-year survival rate for breast cancer is 90 percent, and the 10-year survival rate is 83 percent. This is an average of all stages and grades.

Is invasive lobular carcinoma slow growing?

Invasive lobular carcinoma is known for being a slow growing tumor, usually grade I or II. Slow growing, grade I tumors don’t usually respond well to chemotherapy, so hormonal therapy is key for this type of cancer.

What does invasive lobular carcinoma look like on ultrasound?

The most common sonographic appearance is that of a heterogeneous, hypoechoic mass with angular or ill-defined margins and posterior acoustic shadowing.

Is invasive lobular carcinoma inherited?

Women with a rare inherited condition called hereditary diffuse gastric cancer syndrome have an increased risk of both stomach (gastric) cancer and invasive lobular carcinoma. Women with certain inherited genes may have an increased risk of breast and ovarian cancers.

Should I have a mastectomy for DCIS?

Mastectomy involves removal of the whole breast and is usually recommended if the DCIS affects a large area of the breast, if it has not been possible to get a clear area of normal tissue around the DCIS by wide local excision, or if there is more than one area of DCIS.

Why are lobular cancers sneaky?

Instead of clustering together, lobular cells spread out single file like tree branches or spider webs or mesh, which explains why surgeons and oncologists often refer to it as “sneaky” or “insidious.” Because the cells don’t stick together well, there’s often no lump, making it harder for women to find during self-

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Does Chemo shrink lobular breast cancer?

Chemotherapy may be recommended after surgery to kill any cells that may remain. Chemotherapy can also be used before surgery to shrink a tumor that is large. For women with larger tumors, chemotherapy before surgery may make it possible to choose lumpectomy over mastectomy.

How long can you live with invasive lobular carcinoma?

Outlook for Invasive Lobular Carcinoma

In general, about 90% of all women with breast cancer live at least 5 years after diagnosis.

How treatable is invasive lobular carcinoma?

ILC is treated with a lumpectomy or mastectomy, depending on the size and location of the tumor. In addition, your medical oncologist and radiation oncologist may recommend chemotherapy and/or radiation. Hormonal therapy is nearly always part of the treatment for lobular cancers.

What stage is lobular carcinoma in situ?

Stage 0 means the cancer cells are still within the breast lobule and have not invaded deeper into the surrounding fatty breast tissue. This is called lobular carcinoma in situ (LCIS), a non-invasive breast cancer. In stage 0 cancer, the cancer has not spread to lymph nodes or distant sites.