Is neuroblastoma a brain Tumour?
Despite the name, neuroblastoma is not a brain tumor. It is the most common extracranial solid tumor that affects children. There are around 750 new cases per year diagnosed in children under 15 years of age in North America.
Can neuroblastoma spread to the brain?
Relapsed neuroblastoma metastasizes to the CNS as one cause of death. The overall incidence of brain metastasis in neuroblastoma after treatment ranges from 1.7% to 11.7% . No systemic study of metastasis to the CNS as the main site of progression or recurrence in neuroblastoma patients has been reported in China.
Is neuroblastoma a solid tumor?
Neuroblastoma is the most common solid tumor, other than brain tumors, in children.
What is the difference between glioblastoma and neuroblastoma?
Neuroblastoma is initiated in the embryo at a moment when the nervous system (NS) is in full expansion and occasionally genomic damage can lead to neoplasia. Glioma, to the contrary, occurs in the adult brain supposed to be mostly in a postmitotic state.
What is the life expectancy of a child with neuroblastoma?
For children with low-risk neuroblastoma, the 5-year survival rate is higher than 95%. For children with intermediate-risk neuroblastoma, the 5-year survival rate is between 90% and 95%. For children with high-risk neuroblastoma, the-5-year survival rate is around 50%.
How do you know if your child has neuroblastoma?
Symptoms include: Bump or lump in the neck, chest, pelvis or abdomen (belly), or several lumps just under the skin that may appear blue or purple (in infants). Bulging eyes or dark circles under eyes (it may look like the child has a black eye). Diarrhea, constipation, upset stomach or loss of appetite.
Is Stage 4 neuroblastoma curable?
70% of cases at diagnosis have already spread to other areas of the body which places the cancer in a Stage 4 category. The 5-year survival rate for high-risk Neuroblastoma is 50%. 60% of patients with high-risk Neuroblastoma will relapse. Once in relapse, the survival rate drops to less than 5%.
What are the chances of neuroblastoma coming back?
It is estimated that as many as 50-60% of children with high-risk neuroblastoma will eventually suffer a relapse. In children with intermediate- or low-risk neuroblastoma, relapses occur in only 5-15% of cases.
Does neuroblastoma run in families?
Neuroblastoma most often occurs in children who have no family history of the disease. This is called sporadic neuroblastoma. However, in 1–2% of cases, an increased chance of developing neuroblastoma can be inherited from a parent. This is called hereditary neuroblastoma.
Is neuroblastoma fast growing?
Some neuroblastomas grow slowly (and some might even shrink or go away on their own), while others can grow quickly and spread to other parts of the body. Neuroblastoma happens most often in babies and young children. It is rare in children who are more than 10 years old.
What is the most common extracranial solid tumor?
Neuroblastoma is the most common extracranial solid tumor of childhood and represents a neoplastic expansion of neural crest cells in the developing sympathetic nervous system. The primary tumor originates anywhere along the sympathetic chain but most frequently arises from the adrenal gland.