Question: Can p53 act as a biomarker in cancer management and therapy?


Is p53 a biomarker?

Statistical analysis showed that anti-p53 antibodies can be regarded as a specific biomarker of cancer process. The prevalence of anti-p53 antibodies correlated with the degree of cancer malignancy. The increased incidence of anti-p53 antibodies was also associated with higher frequency of mutations in gene p53.

Is p53 a tumor marker?

The P53 marker is a tumor antigen that hosts mutations. It is also one of the most common alterations observed in human cancers [8]. It is suggested that tumor growth is caused by various phases of genetic damage that can lead to disorderliness in the mechanisms of cell cycle regulation [9].

What is p53 and what role does it play in cancer?

By stopping cells with mutated or damaged DNA from dividing, p53 helps prevent the development of tumors. Because p53 is essential for regulating DNA repair and cell division, it has been nicknamed the “guardian of the genome.”

What is the role of p53 in cancer?

p53 is a nuclear transcription factor with a pro-apoptotic function. Since over 50% of human cancers carry loss of function mutations in p53 gene, p53 has been considered to be one of the classical type tumor suppressors. Mutant p53 acts as the dominant-negative inhibitor toward wild-type p53.

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What is the p21 gene?

Cyclin-dependent kinase inhibitor 1, also known as CDK-interacting protein 1, or more simply as p21, is a cell cycle inhibitor that promotes both CDK/cyclin inhibition as well as cell cycle arrest during the G1/S phase. In humans, p21 is encoded by the CDKN1A gene on chromosome six.

How is p53 mutation detected?

Methods used for the detection of P53 mutations are based either on genomic DNA or mRNA as a template (11,12,15). The most widely used methods are based on DNA sequencing. However, few studies exist that compare sequencing assays by using both RNA and DNA targets (18–22).

Does everyone have a p53 gene?

We just have to hope it doesn’t make the mistake in p53! In fact, these kinds of mutations can happen to anyone. Most people that get cancer actually have both of their p53 gene copies mutated, just from random chance.

Is p53 associated with hereditary cancers?

The majority of sporadic cancers exhibit loss of p53 activity due to mutations or deletions of TP53, and alterations in its signaling pathway. Germline TP53 mutations have been identified in a group of families exhibiting a rare but highly penetrant familial cancer syndrome, called the Li-Fraumeni syndrome (LFS).

How often is p53 mutated in cancer?

The p53 gene contains homozygous mutations in ~50–60% of human cancers. About 90% of these mutations encode missense mutant proteins that span ~190 different codons localized in the DNA-binding domain of the gene and protein.

How do healthy cells become cancerous?

Cancer cells have gene mutations that turn the cell from a normal cell into a cancer cell. These gene mutations may be inherited, develop over time as we get older and genes wear out, or develop if we are around something that damages our genes, like cigarette smoke, alcohol or ultraviolet (UV) radiation from the sun.

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