Is CA125 sensitive?
The sensitivity and specificity of CA125 is known to be poor. It is only raised in approximately 50% of stage 1 epithelial ovarian cancers and in 75–90% of patients with advanced disease.
How accurate is CA125 in detecting ovarian cancer?
Results: Using a CA125 cutoff of 30 U/mL, an overall sensitivity of 94.8% (96.6% specificity) was obtained when comparing malignancies versus healthy postmenopausal controls, whereas a cutoff of 65 U/mL provided a sensitivity of 83.9% (99.6% specificity).
Can you still have cancer if your CA 125 is normal?
Results of the CA 125 test are measured in units per milliliter (U/mL). The normal value is less than 46 U/mL. If your CA 125 level is higher than normal, you may have a benign condition, or the test result could mean that you have ovarian, endometrial, peritoneal or fallopian tube cancer.
How often is ca 125 elevated in ovarian cancer?
About 80% of patients with ovarian cancer exhibited elevated CA125 levels measured using this homologous double determinant assay, while only 1% of healthy women in the study had elevated CA125 levels beyond 35 U/mL.
What is a bad CA125 level?
In the patient who is being evaluated for a pelvic mass, a CA 125 level greater than 65 is associated with malignancy in approximately 90% of cases. However, without an obvious pelvic mass, this association is much weaker.
Can stress cause CA125 to rise?
The most popular current theories suggest that CA 125 is synthesized by mesothelial cells in response to stress, which can be either mechanical stress caused by fluid overload, or inflammatory stress instigated by the release of mediators such as TNFα and interleukins [5,6].
Can you be fully cured of ovarian cancer?
Around two in ten women with advanced-stage ovarian cancer are effectively cured and survive at least 12 years after the treatment as per the research. Your response to cancer therapy and chances for a cure depend on the type and the staging of ovarian cancer at the time of diagnosis.
What cancers does CA125 detect?
Cancer antigen 125 (CA125) is a protein found on most ovarian cancer cells that is secreted into the blood stream and can be measured.
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The CA125 blood levels can be increased in ovarian cancer and other cancers including:
- uterine.
- fallopian tube.
- pancreatic.
- breast.
- colorectal.
- lung.
- stomach.
Does high CA 125 always mean cancer?
Does a high CA-125 always mean cancer? No, a high CA-125 does not always mean cancer is present. Generally speaking, the normal range of CA-125 is considered to be 0-35 units/mL, while a level above 35 units/mL is considered to be a high CA-125 level.
What level of CA 125 indicates cancer?
While a CA 125 level over 35 may indicate cancer, it does not always mean the person has cancer. A CA 125 level over 35 is only a potential indicator.
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CA 125 Levels Chart.
| CA 125 Levels (units/mL) | Potential Cancer |
|---|---|
| 0 – 35 (normal) | Unlikely to have cancer. 99% of the time, it means no cancer. |
What happens if my CA 125 is high?
If you are not being treated for ovarian cancer and your results show high CA-125 levels, it can be a sign of cancer. But it may also be a sign of a noncancerous condition, such as: Endometriosis, a condition in which tissue that normally grows inside the uterus also grows outside the uterus. It can be very painful.