What stage of the cell cycle does chemotherapy affect?
DNA replication occurs during the S phase (synthesis) of the cell cycle. Many chemotherapy drugs act during DNA replication. Some are incorporated into the newly replicated DNA and cause problems. Others interfere with enzymes necessary for DNA replication.
Which phase of the cell cycle is most affected by chemotherapy?
By contrast, the S phase is the synthetic phase of the cell cycle. DNA replication is most active in this phase and many chemotherapy agents work in this phase. G 2 represents a time when mostly RNA (and some protein) is actively produced.
Why is chemo given in cycles?
In general, chemotherapy treatment is given in cycles. This allows the cancer cells to be attacked at their most vulnerable times, and allows the body’s normal cells time to recover from the damage.
What happens to dead cells after chemo?
Researchers from Harvard Medical School, Boston, and the Institute for Systems Biology, Seattle, have discovered that the remains of tumor cells killed by chemotherapy or other cancer treatments can actually stimulate tumor growth by inducing an inflammatory reaction.
How quickly do white blood cells regenerate after chemo?
The white cell count generally falls below the normal range about seven to ten days after a chemotherapy treatment and recovers within about a week after that.
Is 12 cycles of chemo a lot?
Use the drug until maximum benefit, then back off and do some sort of maintenance approach. And remember: There is nothing, nothing, nothing magic about 12 cycles.
What are the strongest chemotherapy drugs?
Doxorubicin (Adriamycin) is one of the most powerful chemotherapy drugs ever invented. It can kill cancer cells at every point in their life cycle, and it’s used to treat a wide variety of cancers. Unfortunately, the drug can also damage heart cells, so a patient can’t take it indefinitely.
Which is the shortest phase?
In anaphase, the shortest stage of mitosis, the sister chromatids break apart, and the chromosomes begin moving to opposite ends of the cell. By the end of anaphase, the 2 halves of the cell have an equivalent collection of chromosomes. In telophase, 2 daughter nuclei form.
What is a 21 day chemo cycle?
Each cycle of TC takes 21 days (3 weeks). On the first day of each cycle, you will have docetaxel and cyclophosphamide. You will then have no chemotherapy for the next 20 days. At the end of the 21 days, you will start your second cycle of TC.
What drugs are used in chemotherapy?
Many different kinds of chemotherapy or chemo drugs are used to treat cancer – either alone or in combination with other drugs or treatments.
Examples of alkylating agents include: