What is EGFR in cancer treatment?


What does it mean to have an EGFR mutation for cancer patients?

An EGFR mutation refers to a mutation (damage) to the portion of the DNA in a lung cancer cell which carries the “recipe” for making EGFR (epidermal growth factor receptor) proteins.

What does EGFR stand for in lung cancer?

EGFR (epidermal growth factor receptor) is a protein on cells that helps them grow. A mutation in the gene for EGFR can make it grow too much, which can cause cancer.

How long can you live with EGFR lung cancer?

In patients with EGFR del19 tumors specifically, the median overall survival was 45.7 months. “As many patients with this type of lung cancer eventually acquire resistance to EGFR TKIs, it’s important to consider the order of these therapies to provide patients with as many future treatment options as possible.

What is EGFR therapy?

Epidermal growth factor receptor (EGFR, also known as ErbB-1 or HER-1) inhibitors are medicines that bind to certain parts of the EGFR and slow down or stop cell growth. EGFR is a protein that is found on the surface of some cells that causes cells to divide when epidermal growth factor binds to it.

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What cancers have EGFR mutations?

EGFR Mutation is present in 5.48% of AACR GENIE cases, with lung adenocarcinoma, conventional glioblastoma multiforme, glioblastoma, colon adenocarcinoma, and non-small cell lung carcinoma having the greatest prevalence [4].

What type of cancer is EGFR?

EGFR (epidermal growth factor receptor, also known as ERBB1 and HER1) is a gene that encodes for the epidermal growth factor receptor protein. Missense mutations, deletions, and insertions are observed in cancers such as lung cancer and glioblastoma.

Is EGFR lung cancer curable?

Lung cancer is treatable. The outlook for people with EGFR lung cancer is improving with the use of targeted therapies. However, while EGFR inhibitors can control cancer progression for months or years, it’s not a cure.

What are the newest treatments for lung cancer?

Today, the U.S. Food and Drug Administration approved Lumakras (sotorasib) as the first treatment for adult patients with non-small cell lung cancer whose tumors have a specific type of genetic mutation called KRAS G12C and who have received at least one prior systemic therapy.

Who has survived lung cancer?

Meet 5 Inspirational Lung Cancer Survivors

  • Juanita Segura – Inspired by Faith and Family. …
  • Lysa Buonanno – Lung Cancer Survivor Inspired to Celebrate. …
  • Terri Conneran – Asthma or Lung Cancer? …
  • David Sturges – Lung Cancer Survivor Advocate for Research. …
  • Michael Weitz – Survivor and Ardent Advocate for Research.

How long can you live with incurable lung cancer?

Life Expectancy for Inoperable Lung Cancer

About 20.5% of people who have any kind of lung cancer live at least 5 years after diagnosis. This 5-year survival rate is 24% overall for non-small-cell lung cancer and 6% overall for small-cell lung cancer.

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Is EGFR mutation hereditary?

In some lung cancer patients this gene, called “EGFR”, contains a DNA change known as an “inherited EGFR mutation”. Early data indicate that these inherited EGFR mutations may be associated with an increased risk of lung cancer. So far, only a small number of families have been found to carry inherited EGFR mutations.