Which tumor marker is more specific for liver cancer?
Total AFP has the sensitivity of 60% and specificity of 90% for the detection of HCC. Increase in the percentage of AFP-L3 over the total AFP (>10%) is very specific for small HCC. PIVKA-II is also more specific than total AFP in detecting HCC.
Is there a marker for liver cancer?
Alpha-fetoprotein (AFP) is used as a tumor marker to help detect and diagnose cancers of the liver, testicles, and ovaries.
What are 3 tumor markers?
Types of Tumor Markers
- Prostate-specific antigen (PSA)
- Prostatic acid phosphatase (PAP)
- CA 125.
- Carcinoembryonic antigen (CEA)
- Alpha-fetoprotein (AFP)
- Human chorionic gonadotropin (HCG)
- CA 19-9.
Can you have liver cancer with normal blood tests?
Hepatocellular carcinoma (HCC or liver cancer) cannot be diagnosed by routine blood tests. There is only one specific blood test which can be used towards a diagnosis of HCC. This test specifically measures for the levels of the protein alfa-fetoprotein in serum (AFP).
What is Liver Tumor markers?
Tumor markers are substances made by cancer cells or by normal cells in response to cancer in the body. High levels of AFP can be a sign of liver cancer or cancer of the ovaries or testicles, as well as noncancerous liver diseases such as cirrhosis and hepatitis.
What blood tests indicate liver cancer?
Alpha-fetoprotein blood (AFP) test
AFP is a protein that can be found in high levels in adults with liver disease, liver cancer, who are pregnant, or other cancers. If AFP levels are very high in someone with a liver tumor, it can be a sign that liver cancer is present.
What is the normal range for cancer markers?
Normal range: < 2.5 ng/ml. Normal range may vary somewhat depending on the brand of assay used. Levels > 10 ng/ml suggest extensive disease and levels > 20 ng/ml suggest metastatic disease.
Are lesions on the liver serious?
Liver lesions are abnormal growths that may be noncancerous (benign) or cancerous. Benign lesions occur for a variety of reasons and are typically not cause for concern. Liver cancer is less common but more serious.
What are the most common tumor markers?
Tumor Markers in Common Use
- ALK gene rearrangements and overexpression. …
- Alpha-fetoprotein (AFP) …
- B-cell immunoglobulin gene rearrangement. …
- BCL2 gene rearrangement. …
- Beta-2-microglobulin (B2M) …
- Beta-human chorionic gonadotropin (Beta-hCG) …
- Bladder Tumor Antigen (BTA) …
- BRCA1 and BRCA2 gene mutations.
What is a bad CA 125 level?
In the patient who is being evaluated for a pelvic mass, a CA 125 level greater than 65 is associated with malignancy in approximately 90% of cases. However, without an obvious pelvic mass, this association is much weaker.