Evidence for Estrogen Receptor Signaling in Colon Cancer
Can estrogen cause colon cancer?
Historically linked to carcinogenesis in reproductive organs, estrogens have also been implicated in the pathogenesis of different cancer types of non-reproductive tissues including the colon. ERβ is the predominant estrogen receptor expressed in both normal and malignant colonic epithelium.
Which type of cancer is caused by estrogen?
Estrogen-dependent cancers include breast cancer and colorectal cancer. Studies of these cancers are discussed.
Can Hormone Replacement cause colon cancer?
Rectal cancer incidence was not associated with HRT. Conclusion: The risk of colon cancer may be decreased among recent postmenopausal HRT users. Although data are limited, the risk of fatal colon cancer also may be lower in HRT users.
Does cancer feed on estrogen?
Not all cancers are fueled by hormones. But a few types can be, such as: Breast cancer. Some types need estrogen and progesterone to grow.
Does estrogen cause colon polyps?
In our study, we found estrogen significantly depressed the microvessel densities in DMH-induced colon polyps. Accordingly, our study indicated that estrogen reduced the expression of VEGF and HIF-1α in DMH-induced colon polyps.
What is the success rate of hormone therapy?
The 6-year survival rate for HRT users was 92% compared with 80% for nonusers (P = . 05) (Figure 2). Figure 3 shows survival curves for patients with tumors detected by palpation. The 6-year survival rate was 79% for HRT users compared with 76% for nonusers (P = .
Is estrogen positive breast cancer slow growing?
Estrogen receptor/progesterone receptor (ER/PR) positive breast cancers tend to grow more slowly than ER/PR negative cancers, and are more likely to respond to hormone therapy. Approximately two-thirds of breast cancers are ER and/or PR positive.
Can low estrogen cause cancer?
Although estrogen alone improves the symptoms of menopause, it increases the risk of cancer of the uterus ( endometrial cancer).
What is hormone therapy for colon cancer?
Hormone replacement therapy (HRT) use has shown to be associated with a reduced risk of colorectal cancer, however, its impact on survival among women with colorectal cancer remains uncertain. This meta-analysis aimed to systematically assess the survival benefit of HRT use in patients with colorectal cancer.
Can hormones cause colon polyps?
(19) found that a statistically significantly reduced risk for distal adenomas was associated with ever use of hormones. In a colonoscopy-based study, Potter et al. (20) found that 5 or more years of hormone use was inversely associated with prevalent polyps, but no anatomic subsite data were reported.
Does hormone therapy cause polyps?
HRT is also associated with the occurrence of malignancy in endometrial polyps. This may be due to the oestrogenic effect on the uterus.